{"id":4536,"date":"2018-09-18T15:04:01","date_gmt":"2018-09-18T15:04:01","guid":{"rendered":"https:\/\/maat.swebwp.oci.eu\/?p=4536"},"modified":"2023-09-25T14:02:53","modified_gmt":"2023-09-25T14:02:53","slug":"maat-pharma-presents-product-analysis-of-its-first-in-class-high-diversity-microbiome-therapeutic","status":"publish","type":"post","link":"https:\/\/maat.swebwp.oci.eu\/fr\/maat-pharma-presents-product-analysis-of-its-first-in-class-high-diversity-microbiome-therapeutic\/","title":{"rendered":"MaaT Pharma Presents Product Analysis of Its First-in-Class High Diversity Microbiome Therapeutic"},"content":{"rendered":"[vc_row type=\u00a0\u00bbin_container\u00a0\u00bb full_screen_row_position=\u00a0\u00bbmiddle\u00a0\u00bb column_margin=\u00a0\u00bbdefault\u00a0\u00bb column_direction=\u00a0\u00bbdefault\u00a0\u00bb column_direction_tablet=\u00a0\u00bbdefault\u00a0\u00bb column_direction_phone=\u00a0\u00bbdefault\u00a0\u00bb scene_position=\u00a0\u00bbcenter\u00a0\u00bb text_color=\u00a0\u00bbdark\u00a0\u00bb text_align=\u00a0\u00bbleft\u00a0\u00bb row_border_radius=\u00a0\u00bbnone\u00a0\u00bb row_border_radius_applies=\u00a0\u00bbbg\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb shape_divider_position=\u00a0\u00bbbottom\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb][vc_column column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; width=\u00a0\u00bb1\/6&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][\/vc_column][vc_column column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; width=\u00a0\u00bb2\/3&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][vc_column_text]\n<h3>Results from <em>in silico<\/em> analysis using MaaT Pharma\u2019s data analysis platform, GutPrint, demonstrate therapeutic rationale and manufacturing capabilities of developing a high diversity biological drug product<\/h3>\n[\/vc_column_text][vc_column_text]Lyon, France,<strong> September 18, 2018<\/strong> \u2013 MaaT Pharma announced today the presentation of the analysis of MaaT Pharma\u2019s lead biotherapeutic, MaaT013, demonstrating its drug product characteristics using MaaT Pharma\u2019s proprietary big data analysis platform, GutPrint<span style=\"font-size: 9px;\">\u00ae<\/span>. The results of the study form the foundation of MaaT Pharma\u2019s approach to create standardized and reproducible high diversity microbiome therapeutics to treat life-threatening diseases. MaaT Pharma\u2019s Bioinformatics Manager, Lilia Boucinha, Ph.D. presented the data at the 2018 European Molecular Biology Organization (EMBO) Symposium \u2013 The Human Microbiome, being held from September 16 \u2013 19, 2018 at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany.[\/vc_column_text][nectar_single_testimonial testimonial_style=\u00a0\u00bbsmall_modern\u00a0\u00bb color=\u00a0\u00bbExtra-Color-2&Prime; quote=\u00a0\u00bb\u201cAlterations in the microbiome, also called dysbiosis, have been implicated in a wide-range of diseases, and re-establishing its function has been scientifically and clinically validated as a therapeutic approach. We have developed our lead biotherapeutic product, MaaT013, based on our fundamental belief that high microbial species richness and diversity are critical to achieving therapeutic impact,\u201d<\/p>\n<p>\u201cThe results we presented today, clearly demonstrate our capabilities to produce a reproducible high diversity cGMP product and we look forward to further evaluating MaaT013 in our ongoing Phase 2 trial in acute Graft-versus-Host Disease patients.\u201d\u00a0\u00bb name=\u00a0\u00bbcommented Herv\u00e9 Affagard\u00a0\u00bb subtitle=\u00a0\u00bbCo-founder and CEO of MaaT Pharma.\u00a0\u00bb][vc_column_text]In the presented study MaaT Pharma\u2019s proprietary biotherapeutic MaaT013 was evaluated in comparison to a single donor approach using MaaT Pharma\u2019s proprietary and validated big data analysis platform GutPrint<span style=\"font-size: 9px;\">\u00ae<\/span>. In comparison to single donor samples, MaaT013 showed significantly increased diversity. Most importantly, diversity within the sample batches was less variable and a greater homogeneity between batches was observed compared to single donor samples. Furthermore, the analysis of the MaaT013 samples showed that there was a 58% increase in the number of microbes (richness) compared to single-donor-based FMT products and less than 5% of Proteobacteria, which are known to include pro-inflammatory species. Taken together, these data strongly highlight MaaT Pharma\u2019s capabilities to produce a cGMP high diversity drug product for clinical evaluation.[\/vc_column_text][nectar_single_testimonial testimonial_style=\u00a0\u00bbsmall_modern\u00a0\u00bb color=\u00a0\u00bbExtra-Color-2&Prime; quote=\u00a0\u00bb\u201cRecent publications in Cell have demonstrated that a complete microbiome approach is critical to restore a functional microbiome in patients and we are very pleased to have the opportunity to present our novel biotherapeutic approach at the prestigious EMBO Symposium on the human microbiome. We established GutPrint\u00ae to assist our development of high microbial diversity &#8211; high richness drug products to restore immune homeostasis and gut barrier integrity in severe diseases and our results give impetus to our rationale for developing a biological drug product which can overcome donor-dependent responses and the limitations of approaches relying on single species or a simple cocktail.\u201d\u00a0\u00bb name=\u00a0\u00bbCommented Dr. Jo\u00ebl Dor\u00e9\u00a0\u00bb subtitle=\u00a0\u00bbScientific Co-founder of MaaT Pharma and senior author on the poster\u00a0\u00bb][vc_column_text]<strong>Poster Discussion Session details:<\/strong><\/p>\n<p><strong>Title<\/strong>: Developing a New Generation of First-in-class High Diversity Microbiome Biotherapeutics to Treat Life-threatening Diseases<\/p>\n<p><strong>Abstract No<\/strong>: <a href=\"https:\/\/maat.swebwp.oci.eu\/docs\/EMBL_POSTER_18_sept_18.pdf\" target=\"_blank\" rel=\"noopener\">64<\/a><\/p>\n<p><strong>Poster Session<\/strong>: II<\/p>\n<p><strong>Date\/Time<\/strong>: September 18, 2018 \/ 16:30 \u2013 18:30<\/p>\n<p><strong>Location<\/strong>: ATC Helix A and B<\/p>\n<p><a href=\"https:\/\/maat.swebwp.oci.eu\/docs\/EMBL_POSTER_18_sept_18.pdf\" target=\"_blank\" rel=\"noopener\">The poster is available<\/a> on the company website following the presentation under \u201cNews\u201d.[\/vc_column_text][\/vc_column][vc_column column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; width=\u00a0\u00bb1\/6&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][\/vc_column][\/vc_row][vc_row type=\u00a0\u00bbin_container\u00a0\u00bb full_screen_row_position=\u00a0\u00bbmiddle\u00a0\u00bb column_margin=\u00a0\u00bbdefault\u00a0\u00bb column_direction=\u00a0\u00bbdefault\u00a0\u00bb column_direction_tablet=\u00a0\u00bbdefault\u00a0\u00bb column_direction_phone=\u00a0\u00bbdefault\u00a0\u00bb scene_position=\u00a0\u00bbcenter\u00a0\u00bb text_color=\u00a0\u00bbdark\u00a0\u00bb text_align=\u00a0\u00bbleft\u00a0\u00bb row_border_radius=\u00a0\u00bbnone\u00a0\u00bb row_border_radius_applies=\u00a0\u00bbbg\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb shape_divider_position=\u00a0\u00bbbottom\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb][vc_column column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; width=\u00a0\u00bb1\/1&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][nectar_highlighted_text color_type=\u00a0\u00bbregular\u00a0\u00bb highlight_color=\u00a0\u00bb#e9a017&Prime; style=\u00a0\u00bbhalf_text\u00a0\u00bb]\n<h3>About <em>MaaT Pharma<\/em><\/h3>\n[\/nectar_highlighted_text][vc_column_text]MaaT Pharma has established the most complete approach to restoring patient-microbiome symbiosis to improve survival outcomes in life-threatening diseases. Committed to treating blood cancers and graft-versus-host disease, a serious complication of allogeneic stem cell transplantation, MaaT Pharma has already achieved proof of concept in acute myeloid leukemia patients. Supporting the further expansion of our pipeline into larger indications, we have built a powerful discovery and analysis platform to evaluate drug candidates, determine novel disease targets and identify biomarkers for microbiome-related conditions. Our therapeutics are produced through a standardized cGMP manufacturing and quality control process to safely deliver the full diversity of the microbiome. MaaT Pharma benefits from the commitment of world-leading scientists and established relationships with regulators to spear-head microbiome treatment integration into clinical practice.[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=\u00a0\u00bbin_container\u00a0\u00bb full_screen_row_position=\u00a0\u00bbmiddle\u00a0\u00bb column_margin=\u00a0\u00bbdefault\u00a0\u00bb column_direction=\u00a0\u00bbdefault\u00a0\u00bb column_direction_tablet=\u00a0\u00bbdefault\u00a0\u00bb column_direction_phone=\u00a0\u00bbdefault\u00a0\u00bb scene_position=\u00a0\u00bbcenter\u00a0\u00bb top_padding=\u00a0\u00bb3%\u00a0\u00bb text_color=\u00a0\u00bbdark\u00a0\u00bb text_align=\u00a0\u00bbleft\u00a0\u00bb row_border_radius=\u00a0\u00bbnone\u00a0\u00bb row_border_radius_applies=\u00a0\u00bbbg\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb shape_divider_position=\u00a0\u00bbbottom\u00a0\u00bb 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therapeutic rationale and manufacturing capabilities of developing a high diversity biological drug product.<\/p>\n","protected":false},"author":2,"featured_media":4333,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[21],"tags":[],"category_press":[],"year_press":[52],"class_list":{"0":"post-4536","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-communiques-de-presse-fr","8":"year_press-52"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.3.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>MaaT Pharma Presents Product Analysis of Its First-in-Class High Diversity Microbiome Therapeutic - MaaT Pharma<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" 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