{"id":16255,"date":"2025-06-26T18:39:50","date_gmt":"2025-06-26T16:39:50","guid":{"rendered":"https:\/\/maat.swebwp.oci.eu\/?page_id=16255"},"modified":"2025-06-27T10:49:57","modified_gmt":"2025-06-27T08:49:57","slug":"joel-dore-itw-microbiome-immune-system","status":"publish","type":"page","link":"https:\/\/maat.swebwp.oci.eu\/fr\/joel-dore-itw-microbiome-immune-system\/","title":{"rendered":"Jo\u00ebl Dor\u00e9 &#8211; ITW Microbiome &#038; Immune System"},"content":{"rendered":"[vc_row type=\u00a0\u00bbfull_width_background\u00a0\u00bb full_screen_row_position=\u00a0\u00bbmiddle\u00a0\u00bb column_margin=\u00a0\u00bbdefault\u00a0\u00bb column_direction=\u00a0\u00bbdefault\u00a0\u00bb column_direction_tablet=\u00a0\u00bbdefault\u00a0\u00bb column_direction_phone=\u00a0\u00bbdefault\u00a0\u00bb bg_image=\u00a0\u00bb760&Prime; bg_position=\u00a0\u00bbcenter center\u00a0\u00bb background_image_loading=\u00a0\u00bbdefault\u00a0\u00bb bg_repeat=\u00a0\u00bbno-repeat\u00a0\u00bb scene_position=\u00a0\u00bbcenter\u00a0\u00bb top_padding=\u00a0\u00bb10%\u00a0\u00bb bottom_padding=\u00a0\u00bb14%\u00a0\u00bb text_color=\u00a0\u00bblight\u00a0\u00bb text_align=\u00a0\u00bbleft\u00a0\u00bb row_border_radius=\u00a0\u00bbnone\u00a0\u00bb row_border_radius_applies=\u00a0\u00bbbg\u00a0\u00bb enable_gradient=\u00a0\u00bbtrue\u00a0\u00bb color_overlay=\u00a0\u00bbrgba(91,192,204,0.94)\u00a0\u00bb color_overlay_2=\u00a0\u00bb#014f90&Prime; 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width=\u00a0\u00bb2\/3&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][split_line_heading animation_type=\u00a0\u00bbdefault\u00a0\u00bb]\n<h1 style=\"text-align: center;\">How Microbiome Research Is Transforming Medicine?<\/h1>\n[\/split_line_heading][\/vc_column][vc_column column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; 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gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb shape_divider_position=\u00a0\u00bbbottom\u00a0\u00bb bg_image_animation=\u00a0\u00bbzoom-out\u00a0\u00bb shape_type=\u00a0\u00bbstraight_section\u00a0\u00bb][vc_column column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; width=\u00a0\u00bb1\/1&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][vc_column_text]<a href=\"https:\/\/maat.swebwp.oci.eu\/fr\/microbiome-et-medecine\/\"><span style=\"color: #000000;\"><span style=\"font-size: 14px;\">Revenir \u00e0 <span style=\"color: #00c8d2;\">Le microbiote en m\u00e9decine : ce qu&rsquo;il faut savoir<\/span><\/span><\/span><\/a>[\/vc_column_text][divider line_type=\u00a0\u00bbNo Line\u00a0\u00bb][vc_row_inner column_margin=\u00a0\u00bb60px\u00a0\u00bb column_direction=\u00a0\u00bbdefault\u00a0\u00bb column_direction_tablet=\u00a0\u00bbdefault\u00a0\u00bb column_direction_phone=\u00a0\u00bbdefault\u00a0\u00bb text_align=\u00a0\u00bbleft\u00a0\u00bb][vc_column_inner column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; width=\u00a0\u00bb3\/4&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][divider line_type=\u00a0\u00bbNo Line\u00a0\u00bb][vc_column_text]\n<h2><span style=\"color: #004e98;\">Dr. Jo\u00ebl Dor\u00e9: A Healthy Microbiome <\/span><span style=\"color: #004e98;\">\u201c<\/span><span style=\"color: #004e98;\">Is a Control Hub for Health\u201d<\/span><\/h2>\n[\/vc_column_text][vc_column_text]\n<p data-start=\"249\" data-end=\"691\"><span style=\"font-size: 21px;\">To mark <strong>World Microbiome Day 2025<\/strong>, we sat down with <strong>Jo\u00ebl Dor\u00e9<\/strong>, Research Director at INRAE and Scientific advisor and co-founder of MaaT Pharma, and one of the world\u2019s leading microbiome experts.\u00a0<\/span><span style=\"font-size: 21px;\">He shares why the microbiome is more crucial than ever, how to care for it daily, and what the future of microbiome-based medicine could look like. From everyday tips to breakthrough therapies, discover why the gut microbiome is becoming a cornerstone of modern health.<\/span><\/p>\n<p data-start=\"249\" data-end=\"691\"><span style=\"font-size: 21px;\"><strong>To learn more, read the full interview below &#x1f447;<\/strong><\/span><\/p>\n[\/vc_column_text][\/vc_column_inner][vc_column_inner column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; width=\u00a0\u00bb1\/4&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][divider line_type=\u00a0\u00bbNo Line\u00a0\u00bb][divider line_type=\u00a0\u00bbNo Line\u00a0\u00bb][divider line_type=\u00a0\u00bbNo Line\u00a0\u00bb][image_with_animation image_url=\u00a0\u00bb8222&Prime; 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gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb shape_divider_position=\u00a0\u00bbbottom\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb][vc_column column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; width=\u00a0\u00bb1\/1&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][vc_row_inner column_margin=\u00a0\u00bbdefault\u00a0\u00bb column_direction=\u00a0\u00bbdefault\u00a0\u00bb column_direction_tablet=\u00a0\u00bbdefault\u00a0\u00bb column_direction_phone=\u00a0\u00bbdefault\u00a0\u00bb text_align=\u00a0\u00bbleft\u00a0\u00bb][vc_column_inner column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; width=\u00a0\u00bb1\/1&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][vc_column_text]<span style=\"font-size: 21px; color: #004e98;\"><strong>Why does the microbiome matter more than ever in 2025?<\/strong><\/span><\/p>\n<p><em>\u00ab\u00a0No longer confined to the lab, <strong>the microbiome is now recognized as central to human health<\/strong>. Over the years, we have seen clearer <strong>links between our gut microbiome and chronic diseases<\/strong> such as obesity, depression, diabetes, and even cancers. In 2025, addressing chronic inflammation and diseases like the rise in colon cancer in young people requires looking beyond treatment, to the root causes, and looking at what is disrupting the gut microbiome and driving general body inflammation. Scientific studies show that Western populations have lost nearly 50% of the diversity in their gut microbiome \u2014 a decline that reflects modern lifestyle and dietary habits. This loss is not minor: it affects vital functions of the microbiome and threatens our overall health.<\/em><br \/>\n<em><br \/>\nWhen healthy the gut microbiome is \u201ca control hub for health\u201d. Operating in full force it digests dietary fibers producing vital metabolites like short-chain fatty acids beneficial for our cells, it modulates immune function and prevents the proliferation of microbes from our foods and environment, and it maintains the integrity of the gut barrier. More specifically we know how <strong>our gut microbiota supports our natural defenses.<\/strong>\u00a0First, it defends against harmful microbes by occupying space and competing for resources \u2014 a process called competitive exclusion or the barrier effect. Second, it constantly <strong>interacts with the immune system to maintain its balance<\/strong>, helping it stays calm when all is well and respond quickly when needed.<\/em><em>\u00ab\u00a0<\/em><\/p>\n<p><strong>&#x1f449; To know more about <a href=\"https:\/\/youtu.be\/BzcsxbtKZLQ\">gut microbiome<\/a> &amp; immunity, watch the <a href=\"https:\/\/youtu.be\/BzcsxbtKZLQ\">video &#x1f3a5;<\/a><\/strong>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row type=\u00a0\u00bbfull_width_background\u00a0\u00bb full_screen_row_position=\u00a0\u00bbmiddle\u00a0\u00bb column_margin=\u00a0\u00bb50px\u00a0\u00bb column_direction=\u00a0\u00bbdefault\u00a0\u00bb column_direction_tablet=\u00a0\u00bbdefault\u00a0\u00bb column_direction_phone=\u00a0\u00bbdefault\u00a0\u00bb scene_position=\u00a0\u00bbcenter\u00a0\u00bb top_padding=\u00a0\u00bb4%\u00a0\u00bb bottom_padding=\u00a0\u00bb2%\u00a0\u00bb text_color=\u00a0\u00bbdark\u00a0\u00bb text_align=\u00a0\u00bbleft\u00a0\u00bb row_border_radius=\u00a0\u00bbnone\u00a0\u00bb row_border_radius_applies=\u00a0\u00bbbg\u00a0\u00bb color_overlay=\u00a0\u00bbrgba(91,202,204,0.4)\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb shape_divider_position=\u00a0\u00bbbottom\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb shape_type=\u00a0\u00bb\u00a0\u00bb][vc_column column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; width=\u00a0\u00bb2\/3&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][vc_column_text]<span style=\"color: #004e98;\"><strong><span style=\"font-size: 21px;\">What are the best ways people can support their microbiome health today?<\/span><\/strong><\/span><\/p>\n<p><em>\u00ab\u00a0Here are four complementary ways to nurture your gut ecosystem through everyday habits:<\/em><\/p>\n<ul>\n<li><em><strong>Eat a healthy, varied diet across your lifespan<\/strong> \u2014 Fill your plate with diverse plant foods, whole grains, legumes, and richly colored vegetables to feed a wide range of beneficial microbes.<\/em><\/li>\n<li><em><strong>Include fermented foods<\/strong> \u2014 While evidence is still emerging, fermented items (like yogurt, kefir, kimchi) help diversify your gut with live microbes that may provide beneficial functions.<\/em><\/li>\n<li><em><strong>Avoid promoting gut permeability and inflammation<\/strong> \u2014 reduce meat to a maximum of 450g per week and favor fatty fish, rapeseed and olive oil for their omega-3 fatty acids.<\/em><\/li>\n<li><em><strong>Think long-term, not quick fixes<\/strong> \u2014 A consistent, nutrient-rich diet carries more benefit than supplements. The mediterranean diet is a good reference.\u00a0\u00bb<\/em><\/li>\n<\/ul>\n<p><strong>&#x1f449; Learn more about healthy eating and <a href=\"https:\/\/www.inrae.fr\/en\/reports\/towards-healthy-and-sustainable-food\/sustainable-healthy-eating-basics\">gut microbiome<\/a> &#8211;<a href=\"https:\/\/www.inrae.fr\/en\/reports\/towards-healthy-and-sustainable-food\/sustainable-healthy-eating-basics\"> Source INRAe<\/a> <\/strong>[\/vc_column_text][\/vc_column][vc_column column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; width=\u00a0\u00bb1\/3&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][divider line_type=\u00a0\u00bbNo Line\u00a0\u00bb][divider line_type=\u00a0\u00bbNo Line\u00a0\u00bb][divider line_type=\u00a0\u00bbNo Line\u00a0\u00bb][image_with_animation image_url=\u00a0\u00bb16291&Prime; animation=\u00a0\u00bbFade In\u00a0\u00bb hover_animation=\u00a0\u00bbnone\u00a0\u00bb alignment=\u00a0\u00bbcenter\u00a0\u00bb border_radius=\u00a0\u00bbnone\u00a0\u00bb box_shadow=\u00a0\u00bbnone\u00a0\u00bb image_loading=\u00a0\u00bbdefault\u00a0\u00bb max_width=\u00a0\u00bb100%\u00a0\u00bb max_width_mobile=\u00a0\u00bbdefault\u00a0\u00bb][\/vc_column][\/vc_row][vc_row type=\u00a0\u00bbfull_width_background\u00a0\u00bb full_screen_row_position=\u00a0\u00bbmiddle\u00a0\u00bb column_margin=\u00a0\u00bbdefault\u00a0\u00bb column_direction=\u00a0\u00bbdefault\u00a0\u00bb column_direction_tablet=\u00a0\u00bbdefault\u00a0\u00bb column_direction_phone=\u00a0\u00bbdefault\u00a0\u00bb scene_position=\u00a0\u00bbcenter\u00a0\u00bb top_padding=\u00a0\u00bb2%\u00a0\u00bb bottom_padding=\u00a0\u00bb2%\u00a0\u00bb text_color=\u00a0\u00bbdark\u00a0\u00bb text_align=\u00a0\u00bbleft\u00a0\u00bb row_border_radius=\u00a0\u00bbnone\u00a0\u00bb row_border_radius_applies=\u00a0\u00bbbg\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb shape_divider_position=\u00a0\u00bbbottom\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb shape_type=\u00a0\u00bb\u00a0\u00bb][vc_column column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; width=\u00a0\u00bb1\/1&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][vc_column_text]<span style=\"font-size: 21px; color: #004e98;\"><strong>What is a microbiome-based medicine and what are the challenges?<\/strong><\/span><\/p>\n<p><em>\u00ab\u00a0A Microbiome-based medicine refers to a <strong>medical approach that uses or modifies the gut microbiome to improve health<\/strong> \u2014 whether by restoring microbial balance, delivering beneficial bacterial strains, or leveraging the metabolites they produce. Such therapies are evaluated in clinical trials to demonstrate safety and efficacy. Some of the most well-known examples today include fecal biotherapeutics, using fecal matter from healthy donors as starting material to treat Clostridioides difficile infection with two products approved in the U.S. by the FDA, respectively back in 2022 and 2023, that cause mild to severe diarrhea and colitis (inflammation of the colon) and ii) emerging live biotherapeutics \u2014 carefully selected strains.<\/em><\/p>\n<p><em>As microbiome science is still a relatively young field, microbiome-based therapies \u2014 which involve living organisms or their metabolites \u2014 do not fit precisely into traditional drug categories; however <strong>things are evolving with the first products approval in the U.S.<\/strong>, marking a major regulatory milestone for the entire industry, and harmonizing regulatory frameworks could benefit microbiome therapeutics and accelerate patients access across different regions. In the same line to advance the field, scientists (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37414899\/\">Routy et al, 2023 \u2013 Cancer Cell<\/a>) have also identified the <strong>need for standardization<\/strong> \u2013 ensuring consistent protocols for sampling, analysis, and clinical trials and for dedicated technology development \u2013 improving tools for sequencing, modeling, and delivering microbiome-based interventions. <\/em><\/p>\n<p><em>In a major milestone for the field, <a href=\"https:\/\/maat.swebwp.oci.eu\/fr\/8-janvier-2025-maat-pharma-annonce-des-resultats-positifs-pour-letude-pivotale-de-phase-3-ares-evaluant-maat013-dans-la-maladie-aigue-du-greffon-contre-lhote\/\">Phase 3 clinical data released in 2025<\/a> by MaaT Pharma showed high efficacy of a <strong>microbiome-based therapy in hemato-oncology\u2014specifically for acute graft-versus-host disease<\/strong> (aGvHD), a rare and often fatal complication following bone marrow transplantation for the treatment of blood cancers. With a mortality rate over 85% within one year (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34254289\/\">Abedin et al., 2021<\/a> \u2013 British Journal of Haematology), aGvHD has few effective treatments and <a href=\"https:\/\/maat.swebwp.oci.eu\/fr\/patients-et-proches-de-patients\/#microbiote\">gut microbiome restoration<\/a> is bringing hope to patients battling cancer.\u00a0\u00bb<\/em>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=\u00a0\u00bbfull_width_background\u00a0\u00bb full_screen_row_position=\u00a0\u00bbmiddle\u00a0\u00bb column_margin=\u00a0\u00bb50px\u00a0\u00bb column_direction=\u00a0\u00bbdefault\u00a0\u00bb column_direction_tablet=\u00a0\u00bbdefault\u00a0\u00bb column_direction_phone=\u00a0\u00bbdefault\u00a0\u00bb scene_position=\u00a0\u00bbcenter\u00a0\u00bb top_padding=\u00a0\u00bb4%\u00a0\u00bb bottom_padding=\u00a0\u00bb4%\u00a0\u00bb text_color=\u00a0\u00bbdark\u00a0\u00bb text_align=\u00a0\u00bbleft\u00a0\u00bb row_border_radius=\u00a0\u00bbnone\u00a0\u00bb row_border_radius_applies=\u00a0\u00bbbg\u00a0\u00bb color_overlay=\u00a0\u00bbrgba(91,202,204,0.4)\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb shape_divider_position=\u00a0\u00bbbottom\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb shape_type=\u00a0\u00bb\u00a0\u00bb][vc_column column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; width=\u00a0\u00bb2\/3&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][vc_column_text]<span style=\"color: #004e98;\"><strong><span style=\"font-size: 21px;\">Where do you see the microbiome field in the next five years?<\/span><\/strong><\/span><\/p>\n<p><em>\u00ab\u00a0The <strong>recognition of a healthy microbiome as a crucial support for our health<\/strong> and well being is opening a new frontier \u2013 that of a prevention and a medicine of the microbial human. <\/em><br \/>\n<em>Expected innovations will stem from the recognition of a predictive value in microbiome analysis. For example, microbiome testing may predict risk of chronic diseases, their speed of progression or the response to standard therapies. Large cohort studies like <a href=\"https:\/\/lefrenchgut.fr\">Le French Gut<\/a> will deliver the needed reference to, in turn, document the clinical benefits of microbiome analysis. <\/em><br \/>\n<em>In addition, in life threatening conditions with no therapeutic option, restoration of a functional microbiome could <strong>increase chances of survival for many patients<\/strong>. In the treatment of cancers, the combination of microbiome-based prediction of response to immunotherapy and the promotion of treatment efficacy using fecal biotherapeutics is already emerging.\u00a0\u00bb<\/em>[\/vc_column_text][\/vc_column][vc_column column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1&Prime; background_hover_color_opacity=\u00a0\u00bb1&Prime; column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3&Prime; width=\u00a0\u00bb1\/3&Prime; tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][divider line_type=\u00a0\u00bbNo Line\u00a0\u00bb][divider line_type=\u00a0\u00bbNo Line\u00a0\u00bb][image_with_animation image_url=\u00a0\u00bb16278&Prime; 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